Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease

Figure 4 RIP3 reduces inflammation in liver tissue. Following HF diet feeding, RIP3KO mice had reduced expression of TNF-α, CXCL1, and CXCL2 compared to HF diet fed WT mice. ^aP < 0.05 by Mann-Whitney U test, compared to NC diet fed WT group; ^cP < 0.05 by Mann-Whitney U test, compared to HF diet fed WT group. HF: High fat; KO: Knockout; WT: Wild-type; NC: Normal chow; RIP3: Receptor interacting protein kinase-3; TNF-α: Tumor necrosis factor alpha; CXCL1: Chemokine (C-X-C motif) ligand-1; CXCL2: Chemokine (C-X-C motif) ligand-2.