Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine

Figure 10 In control animals (c, C), the perforation after 7 d shows a communication between the lumen and peritoneal cavity, partly closed by a loose cloth with many debris and inflammatory cells [c, HE x 4; C, HE x 10 (control)]. In rats treated with BPC 157 (b, B), the defect was sealed with well-formed granulation tissue. The surrounding mucosa in controls was edematous, and the epithelium shows practically no regenerative activity, while in treated animals, the edema was much less pronounced and the surface epithelium started to migrate over the defect [b, HE x 4; B, HE x 10 (BPC 157)].