Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine

Figure 2 Defect closing or widening [both as % of presentation immediately before therapy (A)]; bleeding time (s); A: after perforation (1 min); B: during application (2 min); C: the period after application (2 min); D: the subsequent 5-min period; E: the period until the end of the observation (15 min). At 1 min post-injury, administration of medication (/kg, 10 mL/2 min bath/rat) at the perforated (5 mm diameter) cecum lesion and cecum (M-mucosa; S-serosa), including BPC 157 (10 μg), NOS blocker L-NAME (5 mg), NOS substrate L-arginine (100 mg) alone or combined, and a saline bath equal volume (controls). Rats were then left after abdominal closure undisturbed until sacrifice, at day 1 or day 7. ^aP < 0.05 at least vs control.