Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine

Figure 1 Blood vessels, filled/appearance or cleared out/disappearance (assessed with a USB microscope camera, Veho discovery VMS-004D-400x USB microscope), as [total % of cecum vessels augmentation/reduction from proximal to distal end = [number of blood vessels (10 vessels assessed) /100] x % of augmentation/reducing of each vasa recta (0 as point immediately before therapy) (A)]. A: after perforation (1 min); B: during application (2 min); C: the period after application (2 min); D: the subsequent 5-min period; E: the period until the end of the observation (15 min). At 1 min post-injury, medication (/kg, 10 mL/2 min bath/rat) administered at the perforated (5 mm diameter) cecum lesion and cecum (M-mucosa; S-serosa), including BPC 157 (10 μg), NOS blocker L-NAME (5 mg), NOS substrate L-arginine (100 mg) alone or combined, and saline bath of equal volume (controls). Rats were then left after abdominal closure undisturbed until sacrifice, at day 1 or day 7. ^aP < 0.05 vs control.