Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update

doi:10.3748/wjg.v24.i48.5454

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2018; 24(48): 5454-5461
Published online Dec 28, 2018. doi: 10.3748/wjg.v24.i48.5454

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Figure 5 Glycosylation of prostaglandin-endoperoxide synthase 2 in colorectal cancer. The main form in colorectal cancer tissues is the glycosylated 72 kDa protein. This glycosylated prostaglandin-endoperoxide synthase 2 (PTGS2) is also expressed in several tumor colonic cell lines and can be deglycosylated after incubation of the cells with glucosamine or tunikamycin. After this treatment, PTGS2 is rapidly degraded via proteasomal activity. CRC: Colorectal cancer; PTGS: Prostaglandin-endoperoxide synthase.

Citation: Jaén RI, Prieto P, Casado M, Martín-Sanz P, Boscá L. Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update. World J Gastroenterol 2018; 24(48): 5454-5461
URL: https://www.wjgnet.com/1007-9327/full/v24/i48/5454.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i48.5454