Five years of fecal microbiota transplantation - an update of the Israeli experience

Table 3 Fecal microbiota implantation success and failure

	Valid	No.	Success		Failure		P value
			Number	%	Number	%
Patients	111	111	97	87.42	14	12.6
Male gender	111	47	40	41.23	7	50.0	0.535
Ambulatory	111	78	72	92.32	6	7.7	0.016
Hospitalized	111	33	25	75.82	8	24.2
CDI risk factors
Prior hospitalization	111	80	68	70.13	12	85.7	0.224
Antibiotics use	108	89	77	81.13	12	92.3	0.318
PPI usage	110	37	32	33.33	5	35.7	0.86
Chemotherapy	111	19	17	17.53	2	14.3	0.764
IBD	111	20	18	18.63	2	14.3	0.698
Steroid usage	111	17	13	13.43	4	28.6	0.141
Fever	76	21	19	27.93	2	25.0	0.86
Severe disease	111	20	14	14.43	6	42.9	0.01
Death	111	11	6	6.23	5	37.5	0.001
Adverse events	107	19	15	16.03	4	30.8	0.19
Route: Lower GI FMT	111	50	45	88.02	5	12.0	0.338
Upper GI FMT1	111	24	19	79.22	5	20.8
Capsules FMT	111	37	34	91.92	3	8.1
Frozen stool	111	91	81	89.02	10	11.0	0.272
Fresh stool	111	20	16	80.02	4	20.0
0-1 Previous CDI	107	24	23	24.23	1	8.3	0.214
2+ previous CDI	107	83	72	74.23	11	78.6
Indication							0.824
Refractory	111	29	25	86.22	4	13.8
Recurrent	111	82	72	87.82	10	12.2
Prior therapy
Metronidazole	110	89	80	83.33	9	64.3	0.09
Vancomycin	110	109	95	99.03	14	100.0	0.701
Combination	109	31	27	28.13	4	30.8	0.843
	Valid		Mean	SD	Mean	SD	Sigma
Age (yr)	111		63.2	22.4	73.7	12.1	0.089
Charlson comorbidity score	81		4.82	3.18	6.6	2.32	0.048
Previous CDI episodes (n)	107		2.47	1.7	2.38	0.9	0.864
Time from 1st CDI (d)	89		140.4	200.8	108.56	120.3	0.643
Creatinine (mgl/dL)	76		1.37	1.2	2.19	2.6	0.098
Albumin (mg/L)	54		3.32	0.8	2.76	0.5	0.053
WBC (103/dL)	76		13.6	18.7	15.6	10.4	0.756

¹Upper GI: Gastroscopy, nasogastric tube or through percutaneous endoscopic gastrostomy;

²Percentages referral is the total number of subjects in the cohort;

³Percentages referral is the number of subjects in the specific group. CDI: Clostridium difficile infection; IBD: Inflammatory bowel diseases; PPI: Proton pump inhibitor; GI: Gastrointestinal; FMT: Fecal microbiota implantation; IQR: Interquartile range; WBC: White blood cells; Prior hospitalization: Hospitalization during the 3 mo prior to the FMT; Prior hospitalization: Antibiotics use in the 3 mo prior to the FMT.