Five years of fecal microbiota transplantation - an update of the Israeli experience

Table 2 Fecal microbiota implantation outcome and patients’ follow-up

	Overall		Upper GI		Lower GI		Capsules		P value
	n (valid)	%/IQR	n	%/IQR	n	%/IQR	n	%/IQR
Patients	111 (111)		24	222	50	45	37	33
Response within 7 d	94 (111)	84.72	17	713	42	84	34	92	0.198
Days to response, median	2 (111)	1-2	2	1-3	1	0-2	2	2-3	0.069
No. of patients in follow-up at 6 mo5	99 (99)	89.22	19	793	44	88	36	97
Recurrence at 6 mo	16 (99)	16.22	3	15.83	5	11.40	8	22.20	0.141
Total death	11 (111)	9.92	5	213	6	12	0	0	0.023
Death - unrelated	6 (11)	5.42	4	803	2	33	0	0
Death - CDI-related	3 (11)	2.72	1	203	4	66	0	0
No. of adverse events	19 (107)	17.12	1	43	14	28	4	11	0.006
Success4	97 (111)	87.42	19	793	44	88	34	92	0.338

¹Upper GI: Gastroscopy, nasogastric tube or through percutaneous endoscopic gastrostomy;

²Percentages refer to the total number of subjects in the cohort;

³Percentages refer to the number of subjects in the specific group;

⁴Success: diarrhea-free two months post-fecal microbiota implantation;

⁵Eleven patients died before this endpoint, and one had not yet reached it at study closure. Patients who died before this endpoint from a reason other than Clostridium difficile infection (CDI) and were diarrhea-free were regarded as success, while patients who died before this endpoint from their CDI were considered as failures. CDI: Clostridium difficile infection; IQR: Interquartile range; GI: Gastrointestinal.