Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over

Table 4 Multivariate Cox-regression analysis for the risk of graft loss

	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Donor age	1.23 (0.90-1.68)	0.19	1.15 (0.73-1.81)	0.52
Female donor	1.08 (0.78-1.49)	0.63
Donor BMI
25-29	1.56 (1.05-2.31)	0.08
≥ 30	1.53 (0.95-2.47)	0.07
Cause of death
Cerebrovascular	1.091 (0.75-1.58)	0.65
Others	0.68 (0.34-1.36)	0.28
Donor history of hypertension	1.53 (1.10-2.12)	0.00	1.43 (0.97-2.12)	0.07
Donor history of diabetes	0.99 (0.62-1.58)	0.97
Donor ICU stay	1.00 (0.99-1.00)	0.37
Donor cardiac arrest	0.94 (0.59-1.52)	0.82
Donor last serum sodium level	0.97 (0.96-0.99)	0.01	0.96 (0.94-0.99)	0.00
Donor last serum GOT	1.00 (1.00-1.00)	0.13
Donor last serum GPT	1.00 (1.00-1.00)	0.02	1.00 (1.00-1.00)	0.00
Biopsy findings
Normal	1.00 (0.64-1.59)	0.96
Microsteatosis	1.22 (0.82-1.82)	0.31
Mild macrosteatosis (< 30%)	1.89 (0.93-3.82)	0.07
Moderate macrosteatosis (30%-60%)	0.93 (0.57-1.53)	0.78
Recipient age	1.03 (1.01-1.05)	0.00	1.04 (1.02-1.06)	0.00
HCV+ recipient	1.82 (1.32-2.50)	0.00	2.35 (1.55-3.56)	0.00
HCC presence	1.24 (0.90-1.71)	0.18
MELD	1.03 (1.00-1.06)	0.05
D-MELD	1.00 (1.00-1.00)	0.00	1.00 (1.00-1.00)	0.00
Prothrombin activity	0.99 (0.98-1.00)	0.28
CIT	0.99 (0.99-1.00)	0.13
WIT	1.01 (0.99-1.02)	0.38

HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; ICU: Intensive care unit; GOT: Glutamic-oxaloacetic transaminase; GPT: Glutamic-pyruvic transaminase; HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; MELD: Model for end-stage liver disease; D-MELD: The product of donor age and preoperative MELD; CIT: Cold ischemia time; WIT: Warm ischemia time.