Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis

Table 5 KRAS mutation and microsatellite instability status in adenoma and colorectal cancer groups

KRAS status/mutation type	CRA, n = 27 (%)	CRC, n = 43 (%)	P value
WT	19 (70.4)	32 (74.5)	0.7854
Mutation	8	11
p.Gly12Ala (G12A)	1 (3.7)	0
p.Gly12Ser (G12S)	1 (3.7)	1 (2.3)
p.Gly12Val (G12V)	1 (3.7)	2 (4.6)
p.Gly12Asp (G12D)	3 (11.1)	4 (9.3)
p.Gly13Asp (G13D)	2 (7.4)	4 (9.3)
MSI status
MSS + MSI-L	25 + 2 (100)	34 + 2 (83.7)	0.0382a
MSI-H	0	7 (16.3)

Fisher's exact test.

^aP value < 0.05 were considered statistically significant. WT: Wild; MSI: Microsatellite instability; MSS: Microsatellite stable; MSI-L: Microsatellite instability low; MSI-H: Microsatellite instability high; CRA: Colorectal adenoma; CRC: Colorectal cancer.