Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis

Table 4 Correlation analysis between the relative quantification of microRNAs with the inflammatory genes in adenoma and colorectal cancer samples

Spearman correlation coefficient (r)	miR-21	miR-22	miR-28	miR-34a	miR-135b
CRA
TLR2	0.09	0.29	0.31	0.23	0.09
P value	0.6608	0.1655	0.1266	0.2606	0.6714
TLR4	0.18	0.06	0.18	0.41	0.38
P value	0.3892	0.7926	0.3955	0.0431	0.0598
NFKB1	-0.01	-0.17	-0.21	-0.19	-0.20
P value	0.9796	0.4252	0.3191	0.3650	0.3454
IL1B	0.29	0.15	0.09	0.45	0.38
P value	0.1667	0.4834	0.6555	0.0232	0.0610
IL6	0.30	0.08	0.05	0.26	0.24
P value	0.1430	0.7148	0.8237	0.2136	0.2417
IL8	0.40	0.18	0.17	0.44	0.46
P value	0.0466a	0.4017	0.4273	0.0296a	0.0200a
TNF	-0.21	-0.04	-0.03	-0.05	-0.11
P value	0.3083	0.8638	0.9012	0.8152	0.6084
CRC
TLR2	0.29	0.53	0.18	0.19	-0.14
P value	0.0777	0.0005a	0.2790	0.2408	0.3923
TLR4	0.07	0.34	0.33	0.26	0.05
P value	0.668	0.0377a	0.0401a	0.1216	0.7586
NFKB1	0.18	0.31	0.02	-0.10	-0.30
P value	0.2779	0.0499a	0.8958	0.5462	0.0574
IL1B	0.53	0.43	0.13	0.22	-0.10
P value	0.0004a	0.0055a	0.4139	0.1668	0.5248
IL6	0.54	0.57	0.18	0.21	0.05
P value	0.0004a	0.0002a	0.2813	0.2095	0.7680
IL8	0.53	0.37	0.09	0.23	0.13
P value	0.0005a	0.0180a	0.5734	0.1506	0.4314
TNF	0.26	0.42	0.03	0.08	-0.32
P value	0.1094	0.0071a	0.8406	0.6264	0.0411a

Spearman correlation test.

^aP value < 0.05 were considered statistically significant. CRA: Colorectal adenoma; CRC: Colorectal cancer; TNF: Tumour necrosis factor; IL: Interleukin; NFKB: Nuclear factor kappa B; TLR: Toll-like receptor.