Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis

Table 3 Correlation analysis between the relative quantification of the inflammatory genes and microRNAs with the quantification of Fusobacterium nucleatum in adenoma and colorectal cancer samples

Spearman correlation coefficient (r)	CRA	CRC
TLR2	0.42	0.09
P value	0.1557	0.6335
TLR4	-0.62	-0.01
P value	0.0235a	0.9587
NFKB1	-0.40	-0.04
P value	0.1809	0.8045
IL1B	0.31	0.46
P value	0.3064	0.0066a
IL6	0.01	0.47
P value	0.9716	0.0059a
IL8	-0.07	0.54
P value	0.8166	0.0013a
TNF	0.30	0.23
P value	0.3156	0.2027
miR-21	-0.21	0.26
P value	0.4643	0.1467
miR-22	0.17	0.38
P value	0.5528	0.0331a
miR-28	0.04	0.01
P value	0.8872	0.9413
miR-34a	0.17	0.00
P value	0.5630	0.9905
miR-135b	-0.05	0.22
P value	0.8637	0.2163

Spearman correlation test.

^aP value < 0.05 were considered statistically significant. CRA: Colorectal adenoma; CRC: Colorectal cancer; TNF: Tumour necrosis factor; IL: Interleukin; NFKB: Nuclear factor kappa B; TLR: Toll-like receptor.