Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis

Table 2 Relative quantification of microRNAs in adenoma and colorectal cancer samples compared with adjacent normal tissue samples and colorectal cancer samples relative to the adenoma group

	miR-21	miR-22	miR-28	miR-34a	miR-135b
CRA
RQ median	0.75	0.85	0.73	0.97	2.19
RQ Range	0.15-13.91	0.10-3.05	0.08-2.17	0.12-4.74	0.10-25.13
P value	0.6349	0.1747	0.1904	0.3306	0.0074a
CRC
RQ median	0.53	0.27	0.65	1.38	9.31
RQ Range	0.08-12.53	0.026-2.78	0.11-7.27	0.20-30.0	0.45-74.00
P value	0.1725	< 0.0001a	0.0045a	0.0029a	< 0.0001a
CRC/CRA
RQ median	1.01	0.59	0.77	1.26	2.64
RQ Range	0.15-23.91	0.06-6.07	0.14-8.79	0.18-27.51	0.13-20.96
P value	0.0969	0.5770	0.1271	0.0101a	< 0.0001a

Wilcoxon signed rank test.

^aP value < 0.05 were considered statistically significant. CRA: Colorectal adenoma; CRC: Colorectal cancer; RQ: Relative quantification.