Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis

Table 1 Relative quantification of mRNA expression of the inflammatory genes in adenoma and colorectal cancer samples compared with adjacent normal tissue samples and colorectal cancer samples relative to the adenoma group

	TLR2	TLR4	NFKB1	IL1B	IL6	IL8	TNF
CRA
RQ median	0.87	2.27	1.02	2.27	1.12	3.33	0.75
RQ Range	0.36-10.80	0.32-11.25	0.45-3.38	0.14-76.76	0.09-80.41	0.10-874.50	0.14-2.60
P value	0.2940	0.0003a	0.5360	0.0047a	0.2473	0.0006a	0.0527
CRC
RQ median	2.36	0.74	0.90	4.13	6.67	6.36	0.72
RQ Range	0.31-35.80	0.20-23.42	0.31-8.49	0.13-245.70	0.09-192.80	0.16-194.20	0.06-31.76
P value	< 0.0001a	0.4476	0.9855	< 0.0001a	< 0.0001a	< 0.0001a	0.2391
CRC/CRA
RQ median	1.68	0.54	0.78	4.79	9.40	12.14	0.70
RQ Range	0.22-25.49	0.15-17.22	0.27-7.35	0.15-284.80	0.13-271.80	0.31-370.60	0.06-30.77
P value	< 0.0001a	0.0608	0.1237	< 0.0001a	< 0.0001a	< 0.0001a	0.1560

Wilcoxon signed rank test.

^aP value < 0.05 were considered statistically significant. CRA: Colorectal adenoma; CRC: Colorectal cancer; RQ: Relative quantification; TNF: Tumour necrosis factor; IL: Interleukin; NFKB: Nuclear factor kappa B; TLR: Toll-like receptor.