Effect of photodynamic therapy with (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt on pancreatic cancer cells in vitro and in vivo

Figure 6 (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt-induced photodynamic therapy inhibits the growth of pancreatic carcinoma in vivo. A: Images of Panc-1 tumors at 14 d post-photodynamic therapy (PDT) [8 mg/kg (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt (YLG-1), intratumoral (IT) injection] with or without 100 J/cm² illumination. B: The dynamic changes in pancreatic cancers treated by YLG-1-PDT over 14 d. C: Tumor volumes and weights at the indicated time. D: The hematoxylin and eosin staining of tumor sections acquired at 1, 2, and, 14 d post-PDT. Images were captured under a light microscope (magnification, 200×). The results are expressed as the mean ± SD (n = 3). ^aP < 0.05, ^bP < 0.01, and ^cP < 0.001 vs the Con group at the indicated time. YLG: (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt; PDT: Photodynamic therapy; IT: Intratumoral.