Effect of photodynamic therapy with (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt on pancreatic cancer cells in vitro and in vivo

Figure 3 (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt-induced photodynamic therapy kills pancreatic cancer cells by inducing reactive oxygen species. A: Fluorescence images of intracellular reactive oxygen species (ROS) in SW1990 and Panc-1 cells at 1 h post-photodynamic therapy (PDT) (magnification, 200×). B: Quantitative analysis of ROS production using the scanning multimode reader. C: Effect of the ROS scavenger N-acetyl-L-cysteine on the cytotoxicity induced by (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt-induced PDT. Data are expressed as the mean ± SD (n = 3). ^cP < 0.001 vs Con group, ^dP < 0.001 vs the PDT group. FL: Fluorescence; ROS: Reactive oxygen species; YLG-1: (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt; PDT: Photodynamic therapy; NAC: N-acetyl-L-cysteine.