MicroRNA-15a - cell division cycle 42 signaling pathway in pathogenesis of pediatric inflammatory bowel disease

Figure 5 MicroRNA-15a negatively regulates cell division cycle 42 in pediatric inflammatory bowel disease patients. A: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate the relative mRNA expression of MicroRNA-15a (miR-15a) in every group; (B) qRT-PCR was used to evaluate the relative mRNA expression of cell division cycle 42 (Cdc42) in every group. C: Pearson r test was used to test the correlation of miR-15a and Pediatric Crohn’s disease Activity Index (PCDAI); D: Pearson r test was used to test the correlation between Cdc42 and PCDAI; E: Pearson r test was used to test the correlation between miR-15a and Cdc42 [^aP < 0.05, ^bP < 0.01 vs control, ^cP < 0.05 vs Crohn’s disease active group]. miR: MicroRNA; Cdc42: Cell division cycle 42; qRT-PCR: Quantitative reverse transcription polymerase chain reaction; CD AC: Crohn’s disease active; CD RE: Crohn’s disease remission; UC: Ulcerative colitis; PCDAI: Pediatric Crohn’s Disease Activity Index.