Copyright
©The Author(s) 2018.
World J Gastroenterol. Dec 14, 2018; 24(46): 5271-5279
Published online Dec 14, 2018. doi: 10.3748/wjg.v24.i46.5271
Published online Dec 14, 2018. doi: 10.3748/wjg.v24.i46.5271
All | Responder | Non-responder | P value | |
n | 50 | 40 | 10 | |
Age (yr) | 65.9 ± 10.2 | 66.2 ± 10.2 | 64.7 ± 10.4 | 0.638 |
Gender: Male, n (%) | 34 (68.0) | 25 (63.9) | 9 (90.0) | 0.138 |
Height (m) | 1.63 ± 0.10 | 1.62 ± 0.11 | 1.64 ± 0.08 | 0.695 |
Weight (kg) | 64.7 ± 12.1 | 63.0 ± 11.3 | 71.6 ± 13.4 | 0.044 |
Body mass index (kg/m2) | 24.5 ± 3.92 | 24.3 ± 4.10 | 25.2 ± 3.25 | 0.548 |
Etiology (n) | 0.717 | |||
Cirrhotic/Non-cirrhotic | 48/2 | 39/1 | 9/1 | |
HCV/HBV/Alcohol/Non-viral | 15/6/15/12 | 13/4/11/11 | 2/2/4/1 | 0.717 |
IPH/EHO | 1/1 | 1/0 | 0/1 | |
Child-Pugh | 6.94 ± 1.57 | 6.98 ± 1.62 | 6.80 ± 1.40 | 0.756 |
MELD | 7.26 ± 3.05 | 7.02 ± 2.98 | 8.20 ± 3.33 | 0.281 |
Liver cancer, n (%) | 26 (52.0) | 22 (55.2) | 4 (40.0) | 0.490 |
Splenic volume (mL) | 741 ± 325 | 653 ± 267 | 1092 ± 314 | <0.001 |
Spleen vein diameter (mm) | 10.8 ± 3.60 | 10.3 ± 3.47 | 12.8 ± 3.69 | 0.059 |
Portal diameter (mm) | 12.6 ± 3.45 | 12.3 ± 3.46 | 14.1 ± 3.12 | 0.143 |
Procedure: RFA/IVR/Endoscopy/Others (n) | 14/10/22/4 | 12/8/18/2 | 2/2/4/2 | 0.273 |
APRI | 31.3 ± 17.3 | 31.7 ± 15.6 | 29.0 ± 23.8 | 0.661 |
FIB-4 index | 12.4 ± 5.49 | 12.8 ± 5.65 | 10.9 ± 4.71 | 0.315 |
White blood cells (/μL) | 3149 ± 1039 | 3330 ± 1051 | 2480 ± 681 | 0.020 |
Hemoglobin (g/dL) | 12.0 ± 2.14 | 12.4 ± 1.84 | 10.7 ± 2.82 | 0.026 |
Platelets (× 104/μL) | 4.48 ± 1.07 | 4.50 ± 1.12 | 4.35 ± 0.82 | 0.778 |
Prothrombin time (%) | 66.7 ± 12.5 | 67.1 ± 11.6 | 64.6 ± 16.3 | 0.578 |
Total protein (g/dL) | 7.00 ± 0.70 | 7.02 ± 0.69 | 6.93 ± 0.75 | 0.726 |
Serum albumin (g/dL) | 3.46 ± 0.54 | 3.39 ± 0.53 | 3.72 ± 0.56 | 0.089 |
BUN (mg/dL) | 15.8 ± 5.76 | 15.5 ± 5.53 | 17.3 ± 6.69 | 0.277 |
Serum creatinine (mg/dL) | 0.82 ± 0.21 | 0.80 ± 0.20 | 0.86 ± 0.26 | 0.443 |
AST (IU/L) | 47.4 ± 25.6 | 48.4 ± 23.2 | 43.6 ± 35.2 | 0.602 |
ALT (IU/L) | 36.7 ± 22.9 | 37.5 ± 21.3 | 34.2 ± 30.2 | 0.700 |
Total bilirubin (g/dL) | 1.41 ± 0.83 | 1.40 ± 0.85 | 1.45 ± 0.76 | 0.873 |
HbA1c (%) | 5.98 ± 1.15 | 5.97 ± 1.15 | 6.03 ± 1.23 | 0.901 |
Ammonia (μg/dL) | 66.7 ± 42.0 | 64.3 ± 37.3 | 75.9 ± 58.5 | 0.442 |
AFP (ng/mL) | 33.4 ± 82.7 | 29.0 ± 80.8 | 54.2 ± 95.2 | 0.441 |
PIVKA- II (mAU/mL) | 48.1 ± 68.4 | 51.4 ± 75.7 | 32.8 ± 26.0 | 0.493 |
- Citation: Uojima H, Arase Y, Itokawa N, Atsukawa M, Satoh T, Miyazaki K, Hidaka H, Sung JH, Kako M, Tsuruya K, Kagawa T, Iwakiri K, Horie R, Koizumi W. Relationship between response to lusutrombopag and splenic volume. World J Gastroenterol 2018; 24(46): 5271-5279
- URL: https://www.wjgnet.com/1007-9327/full/v24/i46/5271.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i46.5271