Liver transplantation for critically ill cirrhotic patients: Overview and pragmatic proposals

Table 1 Main retrospective studies on critically ill cirrhotic patients and liver transplant

Author	Study period	n	Definedexclusioncriteria for LT	General severityat LT	MELDat LT	Prognostic factorsofpost-transplantmortality	Post-transplant survival
Umgelter et al[12]	2007-2009	13	Subjective	SOFA19	38	Increasing MELD during first 48 h and longer ICU stay	46% at 1 yr
Karvelllas et al[16]	2000-2009	198	No	SOFA 14	34	Not SOFA	62% at 3 yr
						Recipient age > 60 yr
Duan et al[27]	2004-2012	100	No	SOFA 9	32	LDLT = DDLT	78% at 1 yr
Finkenstedt et al[9]	2002-2010	33	Subjective	RRT 30%	28	No	87% at 1 yr
				MV 9%
Petrowsky et al[13]	2002-2010	133	No	RRT 90%	> 40	MELD	64% at 3 yr
						Age adjusted-Charslon index
				MV 66%		Cardiac risk
						Septic shock
Knaak et al[15]	2000-2013	122	FiO2 > 40%	SOFA 15	32	Glasgow Coma Score < 7 before intubation	76% at 3 yr
			Norepinephrine > 0.1 µg/kg per min
Levesque et al[19]	2008-2013	30 (ACLF3)	No	SOFA 16	37	No	43% at 1 yr
Moon et al[45]	1998-2010	190	No	RRT 43%	38	No	70% at 5 yr
				MV 36%
Artru et al[10]	2008-2014	73 (ACLF3)	No active GI bleeding	SOFA 16	38	No	84% at 1 yr
			Norepinephrine < 3 mg/h
			PaO2/FiO2 < 150 mmHg
Michard et al[44]	2007-2015	55	No	SOFA 16	42	Lactate > 5 mmol/L	60% at 1 yr
						ARDS with PaO2/FiO2 < 200 mmHg
Thuluvath et al[43]	2002-2016	677	No	5 or 6 OF	40	Age, intubation	81% at 1 yr

LT: Liver transplant; SOFA: Sequential organ failure assessment; ICU: Intensive care unit; RRT: Renal replacement therapy; MV: Mechanical ventilation; ARDS: Acute respiratory distress syndrome; DDLT/LDLT: Deceased/living donor liver transplantation; GI: Gastro intestinal; MELD: Model for end-stage liver disease; OF: Organ failure according to CLIF-SOFA.