Glucocorticoid receptor regulates expression of microRNA-22 and downstream signaling pathway in apoptosis of pancreatic acinar cells

Figure 5 Down-regulation of Nr3c1 by using si-Nr3c1 promotes the apoptosis of AR42J cells by suppressing the PI3k/Akt signaling pathway. A: Erb-b2 receptor tyrosine kinase 3 (ErbB3) mRNA expression level; B: ErbB3 protein level; C: The apoptosis rate of AR42J cells after the effect of caerulein for 24 h; D: Amylase level in medium; E: Western blot analysis for p-PI3k, p-Akt, and apoptosis associated proteins in AR42J cells. Data were obtained from three independent experiments in triplicate and are shown as the mean ± SD. ^bP < 0.01 vs siRNA NC groups. ErbB3: Erb-b2 receptor tyrosine kinase 3; Cae: Caerulein; miR-22: MicroRNA-22.