Multidisciplinary approach for post-liver transplant recurrence of hepatocellular carcinoma: A proposed management algorithm

Table 4 Surgery for recurrent hepatocellular carcinoma after liver transplantation

	No. resection/total (%)	Site of resection	Median OS in months		Selection criteria	Resection: Independent predictor of survival
			Overall	Resection/no resection
Comparative study
Roayaie et al[4], 2004	18/57 (31.6)	Liver (n = 8), lung (n = 7), adrenal (n = 2), chest wall (n = 1)1	8.7	-	Technical feasibility	Yes
Kornberg et al[76], 2010	7/16 (43.8)	Liver (n = 2), lung (n = 2), others (n = 3)	10.5	65/55	-	Yes
Valdivieso et al[39], 2010	11/23 (47.8)	Liver (n = 2), lung (n = 2), adrenal (n = 2), abdominal lymph node (n = 2)	-	32.3 ± 21.5/11.9 ± 6.925	Technical feasibility	-
Sapisochin et al[77], 2015	38/121 (31.4)	-	-	31/12/535	Technical feasibility	Yes
Bodzin et al[78], 2017	25/106 (23.6)	lung (n = 8), bone (n = 6), intra-abdominal (n = 4), liver (n = 3), brain (n = 2)	10.6	27.8/10.6/3.735	-	-
Fernandez-Sevilla et al[79], 2017	22/70 (31.4)4	-	19	35/155	Technical feasibility. No progression with systemic treatment	Yes

¹Include radiofrequency ablation of liver lesion (n = 2);

²R0 resection vs no R0 resection;

³Resection vs non-surgical treatment vs best supportive care;

⁴R0/1 resection vs no R0/1 resection;

⁵Statistically significant. OS: Overall survival.