Different distributions of interstitial cells of Cajal and platelet-derived growth factor receptor-α positive cells in colonic smooth muscle cell/interstitial cell of Cajal/platelet-derived growth factor receptor-α positive cell syncytium in mice

Figure 3 Effects of MRS2500 on smooth muscle contractions in the colon. A and C: Effects of MRS2500 on colonic migrating motor complexes (CMMCs) in the proximal and distal colon and summary of the area under the curve (AUC) at 300 s. The data are normalized to the control value (before the application of MRS2500) (n = 8; ^aP < 0.05 vs control; ^cP < 0.05 vs proximal colon). B and D: Representative traces illustrating the effects of the P2Y1 antagonist MRS2500 on the contractions of colonic smooth muscles in the proximal and distal colon of mice and summary of the contractile responses to MRS2500 as indicated by the AUC at 200 s. The data are normalized to the control value (before the application of MRS2500) (n = 8; ^aP < 0.05 vs control; ^cP < 0.05 vs proximal colon). AUC: Area under the curve.