Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer

Figure 5 Epigenetic factor methyl-CpG binding domain protein 1 interacts with zinc finger E-box binding homeobox-1 in pancreatic cancer cells. A and B: Co-immunoprecipitation assay with methyl-CpG binding domain protein 1 (MBD1) or zinc finger E-box binding homeobox-1 (ZEB1) antibody demonstrated that MBD1 interacted with ZEB1 in PANC-1 and MIA PaCa-2 cells; C: Immunofluoresence assay indicated that MBD1 colocalized with ZEB1 in the nucleus in PANC-1 and MIA PaCa-2 cells. MBD1: Methyl-CpG binding domain protein 1; ZEB1: Zinc finger E-box binding homeobox-1.