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©The Author(s) 2018.
World J Gastroenterol. Nov 21, 2018; 24(43): 4928-4938
Published online Nov 21, 2018. doi: 10.3748/wjg.v24.i43.4928
Published online Nov 21, 2018. doi: 10.3748/wjg.v24.i43.4928
Table 1 Clinicopathological data of patients with gastric cancer and their relation with the presence or absence of Helicobacter pylori, Helicobacter pylori-cagA, Epstein-Barr virus and human papil-lomavirus
| HP- | HP+ | CagA- | CagA+ | EBV- | EBV+ | HPV- | HPV+ | ||||||
| n (%) | 38 (13) | 264 (87) | P (95%CI) | 98 (23) | 204 (77) | P (95%CI) | 240 (80) | 62 (20) | P (95%CI) | 294 (97) | 8 (3) | P (95%CI) | |
| Gender | |||||||||||||
| Male | 195 (65) | 25 (66) | 170 (64) | 0.866 (0.46-1.92) | 60 (61) | 135 (66) | 0.400 (0.75-2.04) | 152 (63) | 43 (69) | 0.377 (0.72-2.39) | 192 (65) | 3 (37) | 0.105 (0.75-1.36) |
| Fem | 107 (35) | 13 (34) | 94 (36) | 38 (39) | 69 (34) | 88 (37) | 19 (31) | 102 (35) | 5 (63) | ||||
| Age | |||||||||||||
| ≥ 55 | 201 (67) | 24 (63) | 177 (67) | 0.635 (0.58-2.41) | 65 (66) | 136 (67) | 0.953 (0.61-1.69) | 157 (65) | 44 (71) | 0.409 (0.70-2.38) | 201 (68) | 0 (0) | 0.000 (1.03-1.15) |
| < 55 | 101 (33) | 14 (37) | 87 (33) | 33 (34) | 68 (33) | 83 (35) | 18 (29) | 93 (32) | 8 (100) | ||||
| Localization | |||||||||||||
| Proximal | 104 (34) | 14 (36) | 90 (34) | 0.837 (0.46-1.87) | 37(38) | 67 (33) | 0.400 (0.49-1.33) | 81 (34) | 23 (37) | 0.621 (0.65-2.07) | 100 (34) | 4 (50) | 0.348 (0.47-7.92) |
| Distal | 198 (66) | 25 (64) | 173 (66) | 61 (62) | 137 (67) | 159 (66) | 39 (63) | 194 (66) | 4 (50) | ||||
| Subtype | |||||||||||||
| Intestinal | 166 (55) | 14 (37) | 152 (58) | 0.016 (1.15-4.70) | 48 (49) | 118 (58) | 0.147 (0.88-2.32) | 127 (53) | 39 (63) | 0.159 (0.85-2.70) | 164 (56) | 2 (25) | 0.084 (0.05-1.33) |
| Diffuse | 136 (45) | 24 (63) | 112 (42) | 50 (51) | 86 (42) | 113 (47) | 23 (37) | 130 (44) | 6 (75) | ||||
| TNM | |||||||||||||
| T | |||||||||||||
| T1-T2 | 70 (23) | 10 (27) | 60 (23) | 0.624 (0.38-1.79) | 27 (28) | 43 (21) | 0.212 (0.40-1.22) | 56 (23) | 14 (23) | 0.900 (0.49-1.87) | 65 (22) | 5 (62) | 0.008 (1.37-25.22) |
| T3-T4 | 232 (77) | 28 (73) | 204 (77) | 71 (72) | 161 (79) | 184 (77) | 48 (77) | 229 (78) | 3 (38) | ||||
| N | |||||||||||||
| N0 | 16 (5) | 2 (5) | 14 (5) | 0.992 (0.22-4.55) | 5 (5) | 11 (5) | 0.916 (0.32-2.79) | 13 (5) | 3 (5) | 0.856 (0.31-4.08) | 16 (5) | 0 (0) | 0.498 (0.92-0.97) |
| N1-N3 | 286 (95) | 36 (95) | 250 (95) | 93 (95) | 193 (95) | 227 (95) | 59 (95) | 278 (95) | 8 (100) | ||||
| M | |||||||||||||
| M0 | 141 (47) | 18 (47) | 123 (47) | 0.928 (0.52-2.04) | 48 (49) | 93 (46) | 0.580 (0.71-1.86) | 121 (50) | 20 (32) | 0.011 (1.18-3.85) | 137 (47) | 4 (50) | 0.849 (0.21-3.55) |
| M1 | 161 (53) | 20 (53) | 141 (53) | 50 (51) | 111 (54) | 119 (50) | 42 (68) | 157 (53) | 4 (50) | ||||
| EBV | |||||||||||||
| EBV+ | 62 (20) | 7 (18) | 55 (21) | 0.731 (0.49-2.79) | 9 (9) | 53 (26) | 0.001 (1.63-7.37) | ||||||
| EBV- | 240 (80) | 31 (82) | 209 (79) | 89 (91) | 151 (74) | ||||||||
| HPV | |||||||||||||
| HPV+ | 8 (3) | 0 (0) | 8 (3) | 0.277 (1.01-1.05) | 1 (1) | 7 (3) | 0.222 (0.42-28.41) | 6 (2) | 2 (3) | 0.751 (0.26-6.60) | |||
| HPV- | 294 (97) | 38 (100) | 256 (97) | 97 (99) | 197 (97) | 234 (98) | 60 (97) | ||||||
- Citation: de Souza CRT, Almeida MCA, Khayat AS, da Silva EL, Soares PC, Chaves LC, Burbano RMR. Association between Helicobacter pylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas. World J Gastroenterol 2018; 24(43): 4928-4938
- URL: https://www.wjgnet.com/1007-9327/full/v24/i43/4928.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i43.4928