Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes

Table 2 Range of increased relative risk of pancreatic cancer associated with specific syndromes as summarised by Chen et al[30] and Del Chiaro et al[31]

Gene	Syndrome	Increase relative risk vs general population
		Chen et al[30]	Del Chiaro et al[31]
BRCA2	Hereditary breast and ovarian cancer	2.2-5.9
BRCA1		1.6-4.7
STK11	Peutz-Jeghers syndrome	76.2-139.0	132.0
PRSS1	Hereditary pancreatitis	53-87	50-70
CDKN2A	Familial atypical multiple mole melanoma	14.8-80.0	34-39
MMR	Hereditary nonpolyposis colorectal cancer	0.0-10.7	4.7