Ubiquitin-like modifier activating enzyme 2 promotes cell migration and invasion through Wnt/β-catenin signaling in gastric cancer

Figure 5 Ubiquitin-like modifier activating enzyme 2 promotes gastric cancer migration and invasion in vitro. A: Wound healing assay showed that knock-down of Uba2 inhibited migration of BGC-823 cells, while over-expression of Uba2 promoted migration of SGC-7901 cells (magnification: 50 ×). Data are shown as mean ± SD from three independent experiments; B: Transwell assays showed that knock-down of Uba2 inhibited migratory and invasion properties in BGC-823 cells, and over-expression of Uba2 in SGC-7901 cells showed the opposite effects (magnification: 100 ×). Data are shown as mean ± SD from three independent experiments; C: Alterations of MMP2, c-Myc, and MMP7 in BGC-823 and SGC-7901 cells. ^aP < 0.05, ^bP < 0.001 vs Control; and ^cP < 0.05, ^dP < 0.001 vs EV. EV: Empty vector; MMP: Matrix metalloproteinase; Uba2: Ubiquitin-like modifier activating enzyme 2.