Copyright
©The Author(s) 2018.
World J Gastroenterol. Nov 14, 2018; 24(42): 4738-4749
Published online Nov 14, 2018. doi: 10.3748/wjg.v24.i42.4738
Published online Nov 14, 2018. doi: 10.3748/wjg.v24.i42.4738
Table 2 The CXC chemokines and their receptors
| CXC ligand | Chemokine name | Receptor | ELR domain |
| CXCL1 | Growth-regulated oncogene (Gro-α) | CXCR2 | ELR+ |
| CXCL2 | Growth-regulated oncogene (Gro-β) | CXCR2 | ELR+ |
| CXCL3 | Growth-regulated oncogene (Gro-γ) | CXCR2 | ELR+ |
| CXCL4 | Platelet factor-4 (PF-4) | CXCR3 | ELR⁻ |
| CXCL5 | Epithelial cell-derived neutrophil-activating peptide-78 (ENA-78) | CXCR2 | ELR+ |
| CXCL6 | Granulocyte chemotactic protein-2 (GCP-2) | CXCR1/2 | ELR+ |
| CXCL7 | Neutrophil-activating peptide-2 (NAP-2) | CXCR2 | ELR+ |
| CXCL8 | Interleukin-8 (IL-8) | CXCR1/2 | ELR+ |
| CXCL9 | Monokine induced by interferon-γ (Mig) | CXCR3 | ELR⁻ |
| CXCL10 | Inducible protein-10 (IP-10) | CXCR3 | ELR⁻ |
| CXCL11 | Interferon-inducible T cell alpha chemoattractant (I-TAC) | CXCR3/7 | ELR⁻ |
| CXCL12 | Stromal cell-derived factor-1 (SDF-1) | CXCR4/7 | ELR⁻ |
| CXCL13 | B cell-attracting chemokine-1 (BCA-1) | CXCR5 | ELR⁻ |
| CXCL16 | Scavenger receptor that binds phosphatidylserine and oxidized lipoprotein (SR-PSOX) | CXCR6 | ELR⁻ |
| CXCL17 | VEGF-correlated chemokine-1 (VCC-1) | CXCR8 | ELR+ |
- Citation: Heras SCDL, Martínez-Balibrea E. CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer. World J Gastroenterol 2018; 24(42): 4738-4749
- URL: https://www.wjgnet.com/1007-9327/full/v24/i42/4738.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i42.4738