Ductopenia and cirrhosis in a 32-year-old woman with progressive familial intrahepatic cholestasis type 3: A case report and review of the literature

Figure 1 Microscopic features of the liver biopsies. A: Severe fibrosis in the portal area and formation of hepatocyte nodules (hematoxylin and eosin staining, × 100); B: “Halo sign” at the junction of the portal area and liver parenchyma (Masson staining, × 100); C: Ductopenia; immunohistochemical staining for cytokeratin 19 showed no obvious bile duct hyperplasia (CK19 immunohistochemical staining, × 100); D: Hepatocyte cytoplasm showing copper-associated protein sinking (rhodamine staining, × 400).