Risk of lymph node metastases in patients with T1b oesophageal adenocarcinoma: A retrospective single centre experience

Table 4 Overview of patients with metastatic T1b OAC

Case	EMR tumour histopathology	Treatment after index EMR	Time till metastases (mo)1	Additional treatment	End study outcome	Cause of death	Survival2 (mo)
1	Sm2/3, G3, LVIX, R1	Surgery	4	Chemotherapy	Deceased	OAC	45
2	SmX, G3, LVI+, R1	Surgery	2	None	Alive	/	87
3	SmX, G3, LVI+, R1	Surgery	4	CRT	Deceased	OAC	8
4	Sm2/3, G3, LVI+, R1	Surgery	2	Chemotherapy	Alive	/	55
5	Sm2/3, G3, LVIX, R1	Conservative	38	CRT	Deceased	OAC	40
6	Sm2/3, G2, LVI+, R1	Conservative	4	CRT	Deceased	OAC	9
7	Sm2/3, G2, LVI-, R1	Conservative	3	CRT	Deceased	OAC	31
8	Sm2/3, G2, LVI+, R1	Conservative	4	CRT	Deceased	OAC	18
9	Sm1, G2, LVI-, R1	Conservative	17	EMR T1a, CRT	Alive	/	26
10	Sm2/3, G3, LVI-, R1	Conservative	13	Radiotherapy	Deceased	OAC	30

¹Time from index EMR until LNM/metastatic disease;

²Time from index EMR until the end of the study or death of the patient. EMR: Endoscopic mucosal resection; LNM: Lymph node metastases; Sm1: Submucosal invasion < 500 μm; Sm2/3: Submucosal invasion > 500 μm; G2: Moderately differentiated tumour; G3: Poorly differentiated tumour; LVI: Lymphovascular invasion; R0: Complete resection; R1: Incomplete resection; X: Indefinite; CRT: Chemoradiation therapy; OAC: Oesophageal adenocarcinoma; N/A: Not available.