Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression

Figure 4 Kaplan-Meier survival plots for overall survival and relapse-free survival according to mitogen-activated protein kinase expression and Helicobacter pylori infection status. A: Mitogen-activated protein kinase (MAPK) expression status (negative or positive) and prognosis of all gastric cancer cases. MAPK positive staining includes all cases of 1+, 2+, and 3+. MAPK positive expression detected by immunohistochemical staining cannot predict overall survival or relapse-free survival; B: Kaplan-Meier survival according to MAPK status in Helicobacter pylori (H. pylori) positive gastric cancer cases. MAPK positive expression significantly predicts poor overall survival in H. pylori positive gastric cancer cases, but does not predict relapse free survival. MAPK: Mitogen-activated protein kinase; H. pylori: Helicobacter pylori.