Recovery of natural killer cells is mainly in post-treatment period in chronic hepatitis C patients treated with sofosbuvir plus ledipasvir

Figure 5 Sofosbuvir and ledipasvir therapy modulates the expression of NKp30 and NKp46 on natural killer cells. Flow cytometric analyses of activating receptors NKp30 and NKp46 on natural killer (NK) cells. The graphs display the frequencies and mean fluorescence intensity (MFI) of NKp30 (A-B) and NKp46 (C-D) on NK cells from chronic hepatitis C (CHC) patients during and after Direct-acting antivirals therapy and healthy controls (n = 13). ^aP < 0.05 and ^bP ≤ 0.01 and ^cP ≤ 0.001, different time points of CHC patients vs healthy controls; ^dP < 0.05 and ^eP ≤ 0.01 and ^fP ≤ 0.001, different time points of CHC patients (2 wk, 4 wk, 8 wk, 12 wk, Pt-12 wk, Pt-24 wk vs 0 wk). NK: Natural killer; PBMCs: Peripheral blood mononuclear cells; CHC: Chronic hepatitis C; Ctrl: Healthy controls; Pt: Post of treatment; MFI: Mean fluorescence intensity.