Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression

Table 7 Univariate COX regression analysis

Variable	Overall survival
	HR	95%CI	P value
Gender (man vs women)	0.952	0.498-1.821	0.882
Age (≥ 60 vs < 60)	1.113	0.581-2.130	0.747
Tumour diameter (≥ 40 mm vs < 40 mm)	1.285	0.684-2.413	0.436
Lymph metastasis (yes vs no)	2.667	1.381-5.128	0.003
Tissue differentiation (high and medium vs low)	4.156	1.622-10.656	0.003
Invasive depth (T3/4 vs T1/2)	2.464	1.189-5.104	0.015
HPA expression (positive vs negative)	3.282	1.968-7.475	0.000
MARK expression (positive vs negative)	2.083	1.068-4.065	0.031
H. pylori (positive vs negative)	1.065	0.556-2.045	0.849

HPA: Heparanase; MAPK: Mitogen-activated protein kinase; H. pylori: Helicobacter pylori; HR: Hazard ratio; CI: Confidence interval.