Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression

doi:10.3748/wjg.v24.i40.4565

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2018; 24(40): 4565-4577
Published online Oct 28, 2018. doi: 10.3748/wjg.v24.i40.4565

Table 1 Heparanase and mitogen-activated protein kinase expression in specimens of gastric cancer n (%)

	Cases (n)	Immunohistochemical result				HR (P value)
	Cases (n)	-	+	++	+++	HR (P value)
HPA
Gastric cancer	99	30 (30.3)	16 (16.2)	25 (25.3)	28 (28.3)	35.547 (0.000)
Para-cancer	99	57 (57.6)	11 (11.1)	17 (17.2)	16 (16.2)^b
Normal tissue	25	24 (96.0)	1 (4.0)	0 (0.0)	0 (0.0)^b^d
MAPK
Gastric cancer	99	49 (49.5)	12 (12.1)	19 (19.2)	19 (19.2)	33.303 (0.000)
Para-cancer	99	82 (82.8)	5 (5.1)	6 (6.1)	6 (6.1)^b
Normal tissue	25	23 (92.0)	2 (8.0)	0 (0.0)	0 (0.0)^b

P values < 0.05 were determined using one way analysis of variance (ANOVA):

^bP: Comparison with gastric cancer;

^dP: Comparison with para-cancer tissue. HPA: Heparanase; MAPK: Mitogen-activated protein kinase; HR: Hazard ratio.

Citation: Liu LP, Sheng XP, Shuai TK, Zhao YX, Li B, Li YM. Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression. World J Gastroenterol 2018; 24(40): 4565-4577
URL: https://www.wjgnet.com/1007-9327/full/v24/i40/4565.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i40.4565