Dimensions of hepatocellular carcinoma phenotypic diversity

doi:10.3748/wjg.v24.i40.4536

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2018; 24(40): 4536-4547
Published online Oct 28, 2018. doi: 10.3748/wjg.v24.i40.4536

Table 1 Molecular classifications of human hepatocellular carcinomas

First author	Year	Number of HCCs	Number of groups	Class/subclassnames	Ref.
Lee	2004	91	2	Cluster A-Cluster B	[36,37]
Boyault	2006	56	6	G1-G6	[42]
Chiang	2008	91	5	CTNNB1-proliferation	[58]
Hoshida	2009	232	3	S1-S3	[59]
Désert	2017	1133	4	PP-PV-ECM-STEM	[43]
TCGA network	2017	559	3	iCluster 1-iCluster 3	[92]

HCCs: Hepatocellular carcinomas; TCGA : The Cancer Genome Atlas; CTNNB1: Gene encoding β-catenin; PP: Periportal; PV: Perivenous; ECM: Extracellular matrix; STEM: Stem/progenitor cells.

Citation: Désert R, Nieto N, Musso O. Dimensions of hepatocellular carcinoma phenotypic diversity. World J Gastroenterol 2018; 24(40): 4536-4547
URL: https://www.wjgnet.com/1007-9327/full/v24/i40/4536.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i40.4536