Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines

Figure 1 Change of white blood cell counts (Group A, B and C vs D). A: Absolute number of WBC counts in two groups (Groups A, B and C vs D). WBC gradually decreased after the thiopurine was started in both the mutant (n = 24) and the wild type. The WBC count of the mutant was lower and statistically significant at 6, 8, 10 and 16 wk (P = 0.0271, 0.0037, 0.0051 and 0.0185, respectively); B: Decrease rate of the WBC counts in two groups (Groups A, B and C vs D). The decrease rate was higher in the variants (n = 24) than the wild (n = 72) and statistically significant at 4, 6, 8, 10, 12, 14 and 16 wk (P = 0.004, 0.0001, 0.0012, 0.0022, 0.00001, 0.0264 and 0.0031, respectively). We set 1.0 as the WBC count at the beginning of thiopurines. WBC: White blood cell.