Low glucose metabolism in hepatocellular carcinoma with GPC3 expression

Figure 2 A 60-year-old woman with moderately differentiated hepatocellular carcinoma positive for GPC3 expression (A-E) and a 38-year-old man with poorly differentiated HCC negative for GPC3 (G-J). A-C: ¹⁸F-FDG PET/CT showed slight ¹⁸F-FDG uptake (SUV_max = 3.4, T/NT = 1.54) in the tumour (black arrow in A, white arrows in B and C). D: Moderately differentiated hepatocellular carcinoma (HCC) was diagnosed by pathological examination using HE staining. E: Immunohistochemical analysis revealed positive expression of GPC3. F: Immunohistochemical analysis revealed low expression of GLUT1 in tumour tissue. G-I: ¹⁸F-FDG PET/CT scans showed intense accumulation of ¹⁸F-FDG (SUV_max = 16.5, T/NT = 7.03) in the tumour (black arrow in G, white arrows in H and I). J: Poorly differentiated HCC was confirmed by pathological examination using HE staining. K: Immunohistochemical analysis revealed that the tumour was negative for GPC3 expression. L: Immunohistochemical analysis revealed high GLUT1 expression in tumour tissue.