Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil

Figure 4 CREPT facilitates CRC cell response to 5-FU chemotherapy. A: Cells were treated with 5-FU (50 μg/mL), and CCK-8 assay estimated their viability; B: Annexin V-PI apoptosis detection show that DLD1 cells were less sensitive to 5-FU chemotherapy when CREPT was knocked down; C: SW620 and DLD1 cells were harvested after exposure to 5-FU (50 μg/mL) for 48 h, and western blotting showed that PARP was highly expressed in cells that expressed more CREPT. CRC: Colorectal carcinoma.