Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer

Table 4 Association between the double combined GSTT1/GSTM genotypes and triple combined GSTT1/GSTM/GSTP1, colorectal cancer, tumor progression, and primary site, adjusted for gender, age, smoking, and alcohol consumption

			Colorectal cancer				Tumor progression (TNM) (n = 198)				Primary site
			Case(n = 198)	Control	OR1	95%CI	Non- advanced (n = 60)	Advanced(n = 138)	OR1	95%CI	Colon(n = 81)	Rectum(n = 117)	OR1	95%CI
Double combination of genotypes				n = 738
GSTT1	GTM1
(+)	(+)		68	303	1.00		26	42	1.00		34	34	1.00
(+)	(-)		97	270	1.50	(1.03-2.19)a	21	76	2.40	(1.19-4.85)a	36	61	1.67	(0.88-3.18)
(-)	(+)		19	82	1.00	(0.55-1.84)	8	11	0.74	(0.26-2.15)	7	12	1.70	(0.59-4.94)
(-)	(-)		14	83	0.61	(0.32-1.19)	5	9	1.20	(0.35-4.10)	4	10	2.60	(0.72-9.46)
Triple combination of genotypes				n = 519
GSTT1	GSTM1	GSTP1
(+)	(+)	Ile/Ile	32	96	1.00		12	20	1.00		16	10	1.00
(+)	(+)	Val*	36	126	1.13	(0.61-2.10)	14	22	0.93	(0.34-2.56)	12	17	1.81	(0.67-4.92)
(-)	(+)	Ile/Ile	10	22	1.45	(0.56-3.77)	5	5	0.50	(0.12-2.18)	18	22	1.41	(0.33-5.98)
(-)	(+)	Val*	9	34	0.90	(0.36-2.25)	3	6	1.07	(0.21-5.31)	2	7	4.57	(0.80-26.24)
(+)	(-)	Ile/Ile	42	86	1.52	(0.81-2.83)	8	22	1.78	(0.65-4.86)	11	19	2.58	(0.99-6.75)
(+)	(-)	Val*	55	98	1.85	(1.01-3.36)a	10	42	2.92	(1.05-8.12)a	19	33	2.06	(0.83-5.15)
(-)	(-)	Ile/Ile	9	23	1.27	(0.48-3.40)	3	5	1.25	(0.25-6.19)	1	7	5.47	(0.92-32.60)
(-)	(-)	Val*	5	34	1.27	(0.11-1.08)	1	3	1.01	(0.14-7.42)	2	2	1.88	(0.27-13.33)

¹OR adjusted for age, gender, alcohol and smoking habits and polymorphisms;

^aP < 0.05 vs control; *Ile/Val ou Val / Ile. OR: Odds Ratio.