Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer

Table 3 Distribution of the clinical-histopathological parameters in relation to the polymorphisms in the genes GSTP1, GSTT1, and GSTM1 in patients with colorectal cancer n (%)

Models	Genotypes	Tumor progression (TNM) (n = 201)				Primary site
		Non-advanced 61 (31)	Advanced 140 (69)	OR1	95%CI	Colon	Rectum	OR1	95%CI
GSTP1
Codominant	A/A	31 (51)	62 (44)	1.00		42 (46)	65 (46)	1.00
	A/G	23 (38)	65 (47)	1.37	(0.70-2.66)	38 (41)	64 (45)	0.96	(0.54-1.72)
	G/G	6 (10)	11 (8)	1.14	(0.37-3.50)	11 (12)	12 (8)	0.73	(0.29-1.85)
Dominant	A/A	31 (51)	62 (44)	1.00		42 (46)	65 (46)	1.00
	A/G-G/G	29 (48)	76 (55)	1.32	(0.71-2.48)	49 (53)	76 (53)	0.91	(0.53-1.57)
Recessive	A/A-A/G	54 (90)	127 (92)	1.00		80 (87)	129 (91)	1.00
	G/G	6 (10)	11 (8)	1.00	(0.34-2.95)	11 (12)	12 (8)	0.74	(0.31-1.81)
Overdominant	A/A-G/G	37 (61)	73 (52)	1.00		53 (58)	77 (54)	1.00
	A/G	23 (38)	65 (47)	1.34	(0.70-2.56)	38 (41)	64 (45)	1.02	(0.59-1.77)
Aditivo	-	-	-	1.18	(0.73-1.92)	-	-	0.89	(0.59-1.34)
GSTT1
	+/+	47 (78)	47 (78)	1.00		78 (85)	114 (80)	1.00
	0/0	13 (22)	20 (14)	0.57	(0.26-1.27)	13 (14)	27 (19)	1.47	(0.71-3.06)
GSTM1
	+/+	34 (56)	53 (38)	1.00		45 (49.5)	55 (39)	1.00
	0/0	26 (43)	85 (61)	2.33	(1.23-4.41)a	46 (50.5)	86 (61)	1.49	(0.87-2.57)

¹OR adjusted for age, gender, alcohol and smoking habits and polymorphisms;

^aP < 0.05 vs control. OR: Odds ratio.