Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer

Table 1 Sociodemographic characteristics, risk factors, and polymorphisms GSTT1, GSTM1, GSTP1 A313G in patients with colorectal cancer and controls n (%)

Variables		Case (n = 232)	Control (n = 738)	OR1 (95%CI)
Gender
Male		112 (48)	370 (50)	1.00
Female		120 (52)	368 (50)	2.91 (1.94-4.37)a
Age [yr (mean) ± SD]		(62) ± 12	(48) ± 12
< 62		112 (49)	621 (84)	1.00
≥ 62		120 (51)	117 (16)	8.79 (5.90-13.09)a
Smoking Habit
Non-smoker		130 (56)	465 (63)	1.00
Smoker		102 (44)	273 (37)	1.45 (0.98-2.14)
Alcohol Consumption
Non-drinker		132 (57)	395 (54)	1.00
Drinker		100 (43)	343 (46)	1.28 (0.85-1.91)
GSTP1
Codominant	A/A	227 (43.7)	107 (46.1)	1.00
	A/G	224 (43.2)	102 (44)	1.06 (0.73-1.54)
	G/G	68 (13.1)	23 (9.9)	0.88 (0.48-1.59)
Dominant	A/A	227 (43.7)	107 (46.1)	1.00
	A/G-G/G	292 (56.3)	125 (53.9)	1.02 (0.71-1.45)
Recessive	A/A-A/G	451 (86.9)	209 (90.1)	1
	G/G	68 (13.1)	23 (9.9)	0.85 (0.48-1.50)
Overdominant	A/A-G/G	295 (56.8)	130 (56)	1.00
	A/G	224 (43.2)	102 (44)	1.09 (0.76-1.55)
Additive		-	-	0.97 (0.75-1.27)
GSTT1
	+/+	573 (77.6)	192 (82.8)	1.00
	0/0	165 (22.4)	40 (17.2)	0.65 (0.43-0.98)a
GSTM1
	+/+	385 (52.2)	100 (43.1)	1.00
	0/0	353 (47.8)	132 (56.9)	1.45 (1.06-2.00)a

¹OR adjusted for age, gender, and alcohol and smoking habits and polymorphisms;

^aP < 0.05 vs control. OR: Odds ratio.