Novel targeting approaches and signaling pathways of colorectal cancer: An insight

Table 2 Overview of clinical trials of colorectal cancer

Therapy	Agent	Clinical status	Ref.
Five peptides combination with oxaliplatin-based chemotherapy	Oxaliplatin	Phase II	[34]
Panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) vs FOLFOX4 alone	Fluorouracil, Oxaliplatin	Phase III trial	[35]
Checkpoint inhibitors	Nivolumab and pembrolizumab	Phase 2 study	[36]
Combination vaccine treatment of five therapeutic epitope-peptides	Fluorouracil, irinotecan or oxaliplatin	Phase I	[37]
Autologous dendritic cell based adoptive immunotherapy	-	Phase I-II	[38]
Autologous antigen-activated dendritic cells in the treatment of CRC	-	Phase I-II	[39]
Adjuvant chemotherapy (FOLFOX)	5-fluorouracil (FU)/leucovorin (LV)	Phase III	[40]