Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension

Figure 1 Dotplots showing hepatic gene expression of endothelial NO synthase (A), inducible NO synthase (B), phosphodiesterase-5 (C), soluble guanylate cyclase subunits α1 (D) and soluble guanylate cyclase subunits β1 (E), and serum cyclic guanosine monophosphate concentrations (pmol/mL) (F). Significant differences among groups are corrected for multiple comparisons and denoted by ^aP < 0.05. Gene expression levels are given as fold expression compared to CON. Since iNOS expression in CON was below the detection limit, it was arbitrarily set to “1.0”. iNOS: Inducible NO synthase.