Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis

Figure 2 Histological comparisons between 1%, 2% and 3% dextran sulfate sodium. At the end of 8 d, the difference between DSS concentration was visible in (A) colonic damage (crypt depletion, inflammation, loss of epithelial barrier) compared to control. (B) Histological scores were similar between 2% and 3% DSS, where at the end of 8 d it is possible to visualize (C) the loss of the Ep and (D) infiltration of eosinophils (E) and lymphocytes (L). One-way ANOVA followed by Dunnet post-hoc test. ^aP < 0.05 compared to control. n = 4/DSS group. DSS: Dextran sulfate sodium; Ep: Epithelial layer.