Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis

Figure 1 Comparison between 1%, 2% and 3% dextran sulfate sodium. Experimental colitis was induced by the administration of DSS in drinking water for 7 d at three different concentrations. Were performed daily clinical evaluations for (A) disease activity index and (B) weight loss. At the end of 8 d, animals were euthanized and were collected measurements for (C) colon length, (D) colon weight and (E) spleen weight. Multiple student’s t test for clinical scores and one-way ANOVA followed by Dunnett post-hoc test for colon length, colon weight and spleen weight. ^aP < 0.05 vs control. n = 6/DSS group. DSS: Dextran sulfate sodium.