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©The Author(s) 2018.
World J Gastroenterol. Oct 14, 2018; 24(38): 4403-4411
Published online Oct 14, 2018. doi: 10.3748/wjg.v24.i38.4403
Published online Oct 14, 2018. doi: 10.3748/wjg.v24.i38.4403
Table 2 Characteristics of hepatitis C virus patients at waiting list registration before and after direct-acting antiviral introduction, according to indication to waiting list registration (decompensated liver disease or hepatocellular carcinoma)
| dec-HCV | HCV/HCC | |||||
| Pre-DAA n = 181 (%) | Post-DAA n = 70 (%) | P value | Pre-DAA n = 144 (%) | Post-DAA n = 94 (%) | P value | |
| Gender (male) | 139 (77) | 53 (75.7) | ns | 118 (82) | 82 (87) | ns |
| Age (yr) | 55 ± 8 | 55 ± 9 | ns | 57 ± 7 | 59 ± 6 | 0.03 |
| BMI | 25 ± 3 | 25 ± 4 | ns | 24.7 ± 3 | 25 ± 3.6 | ns |
| Refractory ascites (yes) | 74 (40) | 32 (45.7) | ns | - | - | |
| Blood group | ns | ns | ||||
| 0 | 86 (47.8) | 32 (45.7) | 62 (43) | 35 (39) | ||
| A | 70 (38.4) | 25 (35.7) | 52 (36) | 42 (44) | ||
| AB | 4 (2.2) | 4 (5.7) | 6 (4) | 5 (5) | ||
| B | 21 (11.5) | 9 (12.8) | 24 (17) | 12 (12) | ||
| HCC (yes) | 41 (22.5) | 24 (34.2) | ns | - | - | |
| Comorbidities | ns | ns | ||||
| None | 134 (74.1) | 44 (62.8) | 104 (72.2) | 76 (80) | ||
| HBV | 7 (3.8) | 2 (2.8) | 8 (5.5) | 3 (3.2) | ||
| Alcohol | 34 (18.6) | 19 (27.1) | 26 (18) | 10 (10.6) | ||
| Metabolic | 6 (3.2) | 5 (7.3) | 6 (4.3) | 5 (5.3) | ||
| Child-Pugh classes | ns | 0.01 | ||||
| A | 6 (3.3) | 3 (4.2) | 64 (44.5) | 64 (68) | ||
| B | 67 (37) | 25 (35.7) | 67 (46.5) | 26 (27) | ||
| C | 108 (59.6) | 42 (60) | 13 (9) | 4 (4) | ||
| MELD score | 18.7 ± 6 | 19.3 ± 6 | ns | 11 ± 3.5 | 11 ± 3.4 | ns |
| HCV Genotype1 | ns | ns | ||||
| 1a | 18 (15.1) | 14 (23) | 11 (10.2) | 16 (18.8) | ||
| 1b | 68 (57.1) | 34 (55.7) | 67 (62) | 39 (45.8) | ||
| 2 | 12 (10) | 3 (4.9) | 10 (9.3) | 4 (4.7) | ||
| 3 | 16 (13.4) | 6 (9.8) | 15 (13.9) | 22 (25.8) | ||
| 4 | 5 (3.3) | 4 (6.5) | 5 (4.6) | 4 (4.7) | ||
| SVR achievement | ||||||
| None | 159 (87.8) | 39 (55.7) | 128 (89) | 45 (47.8) | ||
| Before WL registration | 13 (7.1) | 17 (24.2) | 0.004 | 10 (7) | 24 (25.5) | 0.001 |
| IFN based | 13 (7.1) | 2 (2.8) | 10 (7) | 6 (6.3) | ||
| During WL registration | 9 (4.9) | 14 (20) | 0.009 | 6 (4) | 25 (26.5) | 0.001 |
- Citation: Ferrarese A, Germani G, Gambato M, Russo FP, Senzolo M, Zanetto A, Shalaby S, Cillo U, Zanus G, Angeli P, Burra P. Hepatitis C virus related cirrhosis decreased as indication to liver transplantation since the introduction of direct-acting antivirals: A single-center study. World J Gastroenterol 2018; 24(38): 4403-4411
- URL: https://www.wjgnet.com/1007-9327/full/v24/i38/4403.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i38.4403