Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension

doi:10.3748/wjg.v24.i38.4356

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2018; 24(38): 4356-4368
Published online Oct 14, 2018. doi: 10.3748/wjg.v24.i38.4356

Table 6 Relative median of differences (%) ± interquartile range of the parameters portal venous pressure, mean arterial pressure, and heart rate

	CON			FIB			CIR
	NaCl (n = 19)	Sil 0.1 mg/kg (n = 18)	Sil 1.0 mg/kg (n = 18)	NaCl (n = 7)	Sil 0.1 mg/kg (n = 15)	Sil 1.0 mg/kg (n = 7)	NaCl (n = 7)	Sil 0.1 mg/kg (n = 7)	Sil 1.0 mg/kg (n = 10)
	RMD (%) ± IQR	RMD (%) ± IQR	RMD (%) ± IQR	RMD (%) ± IQR	RMD (%) ± IQR	RMD (%) ± IQR	RMD (%) ± IQR	RMD (%) ± IQR	RMD (%) ± IQR
PVP_norm	- 3 ± 7	- 6 ± 10	- 3 ± 6	- 9 ± 11	- 8 ± 8	- 7 ± 6	- 3 ± 7	- 13 ± 7	- 19 ± 26
MAP_norm	- 10 ± 17	- 8 ± 16	- 7 ± 19	- 21 ± 24	- 14 ± 21	- 10 ± 10	- 17 ± 16	- 14 ± 11	- 17 ± 23
HR_norm	- 4 ± 6	- 4 ± 5	- 4 ± 5	- 8 ± 5	- 8 ± 14	- 12 ± 13	- 6 ± 6	- 8 ± 11	- 14 ± 10¹

¹Significant differences (P < 0.05) between Sil 0.1mg/kg and CON or Sil 1.0 mg/kg and CON are marked by an “¹”. RMD: Relative median of differences; IQR: Interquartile range; PVP: Portal venous pressure; MAP: Mean arterial pressure; HR: Heart rate.

Citation: Schaffner D, Lazaro A, Deibert P, Hasselblatt P, Stoll P, Fauth L, Baumstark MW, Merfort I, Schmitt-Graeff A, Kreisel W. Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension. World J Gastroenterol 2018; 24(38): 4356-4368
URL: https://www.wjgnet.com/1007-9327/full/v24/i38/4356.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i38.4356