Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension

Table 5 Median ± interquartile range of the absolute values of body weight, portal venous pressure, mean arterial pressure, and heart rate at different time points

	CON			FIB			CIR
	NaCl (n = 19)	Sil 0.1 mg/kg (n = 18)	Sil 1.0 mg/kg (n = 18)	NaCl (n = 7)	Sil 0.1 mg/kg (n = 15)	Sil 1.0 mg/kg (n = 7)	NaCl (n = 7)	Sil 0.1 mg/kg (n = 7)	Sil 1.0 mg/kg (n = 10)
	Median ± IQR	Median ± IQR	Median ± IQR	Median ± IQR	Median ± IQR	Median ± IQR	Median ± IQR	Median ± IQR	Median ± IQR
Body weight (g)	375 ± 15	370 ± 28	380 ± 27	359 ± 35	363 ± 28	361 ± 24	336 ± 40	350 ± 46	337 ± 15
PVP_0 (mmHG)	6.4 ± 0.7	6.6 ± 0.4	6.3 ± 0.7	6.0 ± 0.9	6.2 ± 1.3	6.2 ± 0.9	6.8 ± 1.6	7.5 ± 1.7	7.7 ± 1.1
PVP_10 (mmHG)	6.0 ± 0.9	6.6 ± 0.6	6.6 ± 0.9	5.7 ± 1.2	5.5 ± 1.3	5.1 ± 1.4	6.8 ± 1.4	7.1 ± 1.6	7.1 ± 2.2
PVP_30 (mmHG)	5.9 ± 0.7	6.3 ± 0.7	6.4 ± 0.8	5.3 ± 1.4	5.4 ± 1.3	4.8 ± 1.4	6.5 ± 1.2	6.6 ± 1.0	6.3 ± 1.3
PVP_60 (mmHG)	5.9 ± 0.7	6.3 ± 0.8	6.4 ± 1.1	5.1 ± 1.2	5.2 ± 1.2	4.8 ± 1.5	6.6 ± 2.0	6.3 ± 1.0	5.8 ± 1.2
MAP_0 (mmHG)	89 ± 12	106 ± 14	101 ± 28	65 ± 30	59 ± 21	58 ± 28	49 ± 19	47 ± 15	60 ± 19
MAP_10 (mmHG)	83 ± 20	94 ± 14	85 ± 27	55 ± 25	45 ± 10	42 ± 8	42 ± 11	41 ± 5	38 ± 16
MAP_30 (mmHG)	79 ± 21	88 ± 17	77 ± 21	50 ± 14	43 ± 12	37 ± 6	41 ± 12	35 ± 8	36 ± 8
MAP_60 (mmHG)	76 ± 21	82 ± 23	74 ± 28	44 ± 11	40 ± 8	37 ± 7	38 ± 3	34 ± 5	34 ± 7
HR_0 (bpm)	373 ± 40	377 ± 47	368 ± 31	320 ± 30	335 ± 30	314 ± 22	307 ± 38	308 ± 76	365 ± 28
HR_10 (bpm)	362 ± 55	383 ± 44	380 ± 50	313 ± 23	339 ± 41	351 ± 29	286 ± 33	316 ± 71	374 ± 22
HR_30 (bpm)	356 ± 57	366 ± 52	373 ± 41	291 ± 20	310 ± 43	310 ± 21	268 ± 40	313 ± 57	350 ± 36
HR_60 (bpm)	347 ± 39	359 ± 43	362 ± 49	284 ± 26	304 ± 41	295 ± 33	254 ± 36	302 ± 47	324 ± 30