Potential involvement of heat shock proteins in pancreatic-duodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study

doi:10.3748/wjg.v24.i37.4263

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Oct 7, 2018 (publication date) through Dec 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2018; 24(37): 4263-4271
Published online Oct 7, 2018. doi: 10.3748/wjg.v24.i37.4263

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Figure 1 Pancreatic-duodenal homeobox-1 overexpression regulated the expression of heat shock proteins in gastric cancer SGC7901 cells. A: Immunoblotting analysis confirmed the enhanced expression of PDX1 protein after PDX1-pcDNA transfection in SGC7901 cells. It also revealed that PDX1 overexpression could downregulate the expression of HSP27, HSP60, and HSP70 proteins in SGC-PDX1 cells; B: Quantitative analysis of the results of immunoblotting indicated that HSP70 protein was significantly decreased in SGC-PDX1 cells. ^aP < 0.05.

Citation: Ma J, Wang BB, Ma XY, Deng WP, Xu LS, Sha WH. Potential involvement of heat shock proteins in pancreatic-duodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study. World J Gastroenterol 2018; 24(37): 4263-4271
URL: https://www.wjgnet.com/1007-9327/full/v24/i37/4263.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i37.4263