Novel methionyl-tRNA synthetase gene variants/phenotypes in interstitial lung and liver disease: A case report and review of literature

Figure 2 Genetic testing results, protein features, and distribution of reported variants within the methionyl-tRNA synthetase protein. A: Sanger sequencing confirmation of the index case and parents, both variants affect highly conserved amino acid residues of the MetRS protein; B: Illustration of MetRS protein domains, location of amino acid changes of the reported variants so far. ¹Variants from our report; ²Variants from Chinese ILLD cases. MetRS: Methionyl-tRNA synthetase; ILLD: Interstitial lung and liver disease.