Differential expression of mucin 1 and mucin 2 in colorectal cancer

Figure 1 Immunohistochemical illustrations of colorectal carcinoma and control colon with mucin 1 and mucin 2 positive expression. A: Representative IHC expression of MUC1 in luminal surface epithelium (arrow) of tumor-changed colon crypt; B: Membranous and extracellular pattern (arrow) of MUC1 expression in neoplastic cells lining the glandular structures of CRC; C: Representative image of MUC1 membranous localization in normal colon crypts; D: Cytoplasmic expression of MUC2 in scattered epithelial cells of the tumor-changed colon crypt (arrow); E: IHC intense reaction of MUC2 expression in the cytoplasm of numerous cancer cells and/or localized in the lumen of the colon crypts (arrow); F: Cytoplasmic expression of MUC2 in majority of goblet cells in normal colon epithelium. Sections were counterstained with hematoxylin. Objective × 40. MUC1: Mucin 1; MUC2: Mucin 2; IHC: Immunohistochemical; CRC: Colorectal cancer.