Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives

doi:10.3748/wjg.v24.i36.4119

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2018; 24(36): 4119-4131
Published online Sep 28, 2018. doi: 10.3748/wjg.v24.i36.4119

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Figure 2 Protective function of the calcium-sensing receptor against inflammation and carcinogenesis in the colon. Left: The CaSR promotes intestinal barrier integrity, potentially by promoting claudin-2 expression, and inhibits the expression of pro-inflammatory cytokines, thus preventing inflammation. Right: The CaSR exerts an anti-tumourigenic effect by counteracting the mitogenic Wnt pathway, preventing β-catenin translocation into the nucleus, which is either sequestered by E-cadherin at the cell junctions or it is degraded by the non-canonical Wnt signalling (Ror2-Wnt5A) and inhibits the expression of mesenchymal and stem cells markers. IL: Interleukin; CaSR: Calcium-sensing receptor.

Citation: Iamartino L, Elajnaf T, Kallay E, Schepelmann M. Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives. World J Gastroenterol 2018; 24(36): 4119-4131
URL: https://www.wjgnet.com/1007-9327/full/v24/i36/4119.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i36.4119